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1

Pharmacokinetics of diclofenac and inhibition of cyclooxygenases 1 and 2: no relationship to the CYP2C9 genetic polymorphism in humans

Julia Kirchheiner, Ingolf Meineke, Nadine Steinbach, Christian Meisel, Ivar Roots, Jürgen Brockmöller

Journal:

British Journal of Clinical Pharmacology

Year:

2003

Language:

english

File:

PDF, 168 KB

english, 2003

2

Implications of pharmacogenetics for individualizing drug treatment and for study design

Christian Meisel, Thomas Gerloff, Julia Kirchheiner, Przemyslaw M. Mrozikiewicz, Przemyslaw Niewinski, Jürgen Brockmöller, Ivar Roots

Journal:

Journal of Molecular Medicine

Year:

2003

Language:

english

File:

PDF, 271 KB

english, 2003

3

Relative potency of proton-pump inhibitors—comparison of effects on intragastric pH

Julia Kirchheiner, Silke Glatt, Uwe Fuhr, Ulrich Klotz, Ingolf Meineke, Thomas Seufferlein, Jürgen Brockmöller

Journal:

European Journal of Clinical Pharmacology

Year:

2009

Language:

english

File:

PDF, 302 KB

english, 2009

4

Opinion: Pharmacogenetics-based therapeutic recommendations — ready for clinical practice?

Kirchheiner, Julia, Fuhr, Uwe, Brockmöller, Jürgen

Journal:

Nature Reviews Drug Discovery

Year:

2005

Language:

english

File:

PDF, 491 KB

english, 2005

5

Rifampicin alters atorvastatin plasma concentration on the basis of SLCO1B1 521T>C polymorphism

Yi-Jing He, Wei Zhang, Yao Chen, Dong Guo, Jiang-Hua Tu, Lin-Yong Xu, Zhi-Rong Tan, Bi-Lian Chen, Zhi Li, Gan Zhou, Bang-Ning Yu, Julia Kirchheiner, Hong-Hao Zhou

Journal:

Clinica Chimica Acta

Year:

2009

Language:

english

File:

PDF, 171 KB

english, 2009

6

Sex-specific differences in side effects of psychotropic drugs: genes or gender?

Haack, Sara, Seeringer, Angela, Thürmann, Petra A, Becker, Thomas, Kirchheiner, Julia

Journal:

Pharmacogenomics

Year:

2009

Language:

english

File:

PDF, 582 KB

english, 2009

7

Impact of the CYP2D6 ultra-rapid metabolizer genotype on doxepin pharmacokinetics and serotonin in platelets

Kirchheiner, Julia, Henckel, Hanns-Benjamin, Franke, Leonora, Meineke, Ingolf, Tzvetkov, Mladen, Uebelhack, Ralf, Roots, Ivar, Brockmöller, Jürgen

Journal:

Pharmacogenetics and Genomics

Year:

2005

Language:

english

File:

PDF, 142 KB

english, 2005

8

Atypical antipsychotics in severe anorexia nervosa in children and adolescents—review and case reports

Claudia Mehler-Wex, Marcel Romanos, Julia Kirchheiner, Ulrike M.E. Schulze

Journal:

European Eating Disorders Review

Year:

2008

Language:

english

File:

PDF, 149 KB

english, 2008

9

Determination of CYP2D6 gene copy number by multiplex polymerase chain reaction analysis

Luis J. Leandro-García, Susanna Leskelä, Cristina Montero-Conde, Iñigo Landa, Elena López-Jimenez, Rocío Letón, Angela Seeringer, Julia Kirchheiner, Alberto Cascón, Mercedes Robledo, Cristina Rodrígue

Journal:

Analytical Biochemistry

Year:

2009

Language:

english

File:

PDF, 273 KB

english, 2009

10

Determination of phenprocoumon, warfarin and their monohydroxylated metabolites in human plasma and urine by liquid chromatography–mass spectrometry after solid-phase extraction

Mike Ufer, Bernd Kammerer, Julia Kirchheiner, Anders Rane, Jan-Olof Svensson

Journal:

Journal of Chromatography B

Year:

2004

Language:

english

File:

PDF, 240 KB

english, 2004

11

Rapid and simple method for the analysis of nateglinide in human plasma using HPLC analysis with UV detection

Steffen Bauer, Elke Störmer, Julia Kirchheiner, Claudia Michael, Jürgen Brockmöller, Ivar Roots

Journal:

Journal of Pharmaceutical and Biomedical Analysis

Year:

2003

Language:

english

File:

PDF, 122 KB

english, 2003

12

Concise guide to the cytochrome P450 system: drug interaction principles for medical practice.

Julia Kirchheiner

Journal:

Acta Psychiatrica Scandinavica

Year:

2003

Language:

english

File:

PDF, 76 KB

english, 2003

13

Drug monitoring in child and adolescent psychiatry for improved efficacy and safety of psychopharmacotherapy

Claudia Mehler-Wex, Michael Kölch, Julia Kirchheiner, Gisela Antony, Jörg M Fegert, Manfred Gerlach

Journal:

Child and Adolescent Psychiatry and Mental Health

Year:

2009

Language:

english

File:

PDF, 432 KB

english, 2009

14

CytochromeP4502C9 phenotyping using low-dose tolbutamide

Alexander Jetter, Martina Kinzig-Schippers, Andreas Skott, Andreas Lazar, Dorota Tomalik-Scharte, Julia Kirchheiner, Monika Walchner-Bonjean, Ursula Hering, Verena Jakob, Michael Rodamer, Wafaâ Jabran

Journal:

European Journal of Clinical Pharmacology

Year:

2004

Language:

english

File:

PDF, 251 KB

english, 2004

15

Effects of fluvastatin and cigarette smoking on CYP2C9 activity measured using the probe S-warfarin

Myong-Jin Kim, Anne N. Nafziger, Angela D. M. Kashuba, Julia Kirchheiner, Steffen Bauer, Andrea Gaedigk, Joseph S. Bertino

Journal:

European Journal of Clinical Pharmacology

Year:

2006

Language:

english

File:

PDF, 127 KB

english, 2006

16

Association ofMDR1genotypes with susceptibility to colorectal cancer in older non-smokers

Elena Osswald, Andreas Johne, Gabriele Laschinski, Farhad Arjomand-Nahad, Uwe Malzahn, Julia Kirchheiner, Thomas Gerloff, Christian Meisel, Przemyslaw M. Mrozikiewicz, Jury Chernov, Ivar Roots, Karla

Journal:

European Journal of Clinical Pharmacology

Year:

2007

Language:

english

File:

PDF, 158 KB

english, 2007

17

Assessment of urinary mephenytoin metrics to phenotype for CYP2C19 and CYP2B6 activity

Tobias Klaassen, Alexander Jetter, Dorota Tomalik-Scharte, Dirk Kasel, Julia Kirchheiner, Ulrich Jaehde, Uwe Fuhr

Journal:

European Journal of Clinical Pharmacology

Year:

2008

Language:

english

File:

PDF, 236 KB

english, 2008

18

Enantiospecific pharmacokinetics of metoprolol in CYP2D6 ultra-rapid metabolizers and correlation with exercise-induced heart rate

Angela Seeringer, Jürgen Brockmöller, Steffen Bauer, Julia Kirchheiner

Journal:

European Journal of Clinical Pharmacology

Year:

2008

Language:

english

File:

PDF, 183 KB

english, 2008

19

Pharmacogenomics and Personalized Medicine—does it fit into a book?

Julia Kirchheiner

Journal:

European Journal of Clinical Pharmacology

Year:

2009

Language:

english

File:

PDF, 55 KB

english, 2009

20

Simultaneous determination of celecoxib, hydroxycelecoxib, and carboxycelecoxib in human plasma using gradient reversed-phase liquid chromatography with ultraviolet absorbance detection

Elke Störmer, Steffen Bauer, Julia Kirchheiner, Jürgen Brockmöller, Ivar Roots

Journal:

Journal of Chromatography B

Year:

2003

Language:

english

File:

PDF, 267 KB

english, 2003

21

The Role of Human CYP2C8 and CYP2C9 Variants in Pioglitazone Metabolism In Vitro

Eugen Muschler, Jawahar Lal, Alexander Jetter, Anke Rattay, Ulrich Zanger, Gregor Zadoyan, Uwe Fuhr, Julia Kirchheiner

Journal:

Basic & Clinical Pharmacology & Toxicology

Year:

2009

Language:

english

File:

PDF, 207 KB

english, 2009

22

Enantiospecific effects of cytochrome P450 2C9 amino acid variants on ibuprofen pharmacokinetics and on the inhibition of cyclooxygenases 1 and 2*

Kirchheiner, Julia, Meineke, Ingolf, Freytag, Georg, Meisel, Christian, Roots, Ivar, Brockmöller, Jürgen

Journal:

Clinical Pharmacology & Therapeutics

Year:

2002

Language:

english

File:

PDF, 214 KB

english, 2002

23

Workshop outcomes report: Initiatives to establish a European Network of pharmacogenetics/genomics and progress

Anke Hilse Maitland-van der Zee, Katherine Aitchison, Julia Kirchheiner

Journal:

European Journal of Pharmaceutical Sciences

Year:

2007

Language:

english

File:

PDF, 147 KB

english, 2007

24

Clinical implications of pharmacogenetics of cytochrome P450 drug metabolizing enzymes

Julia Kirchheiner, Angela Seeringer

Journal:

Biochimica et Biophysica Acta (BBA) - General Subjects

Year:

2007

Language:

english

File:

PDF, 480 KB

english, 2007

25

CYP2D6 genotyping for psychiatric patients treated with risperidone: considerations for cost–effectiveness studies

Rodríguez-Antona, Cristina, Gurwitz, David, de Leon, Jose, Llerena, Adrián, Kirchheiner, Julia, de Mesa, Emma Gutiérrez, Ibarreta, Dolores

Journal:

Pharmacogenomics

Year:

2009

Language:

english

File:

PDF, 923 KB

english, 2009

26

Impact of CYP2C8 and 2C9 polymorphisms on coronary artery disease and myocardial infarction in the LURIC cohort

Haschke-Becher, Elisabeth, Kirchheiner, Julia, Trummer, Olivia, Grünbacher, Gerda, Kainz, Alexander, Boehm, Bernhard O, März, Winfried, Renner, Wilfried

Journal:

Pharmacogenomics

Year:

2010

Language:

english

File:

PDF, 577 KB

english, 2010

27

Characterization of a Functional Promoter Polymorphism of the Human Tryptophan Hydroxylase 2 Gene in Serotonergic Raphe Neurons

Kathrin Scheuch, Marion Lautenschlager, Maik Grohmann, Silke Stahlberg, Julia Kirchheiner, Peter Zill, Andreas Heinz, Diego J. Walther, Josef Priller

Journal:

Biological Psychiatry

Year:

2007

Language:

english

File:

PDF, 1.75 MB

english, 2007

28

Response to Lithium Augmentation in Depression is Associated with the Glycogen Synthase Kinase 3-Beta −50T/C Single Nucleotide Polymorphism

Mazda Adli, Dorothea L. Hollinde, Thomas Stamm, Katja Wiethoff, Martina Tsahuridu, Julia Kirchheiner, Andreas Heinz, Michael Bauer

Journal:

Biological Psychiatry

Year:

2007

Language:

english

File:

PDF, 297 KB

english, 2007

29

Baseline Brain Perfusion and the Serotonin Transporter Promoter Polymorphism

Roberto Viviani, Eun-Jin Sim, Hanna Lo, Petra Beschoner, Nadine Osterfeld, Christiane Maier, Angela Seeringer, Ana Leonor Godoy, Araceli Rosa, David Comas, Julia Kirchheiner

Journal:

Biological Psychiatry

Year:

2010

Language:

english

File:

PDF, 364 KB

english, 2010

30

Influence of CYP2C9 and CYP2D6 Polymorphisms on the Pharmacokinetics of Nateglinide in Genotyped Healthy Volunteers

Dr Julia Kirchheiner, Ingolf Meineke, Göran Müller, Steffen Bauer, Wolfgang Rohde, Christian Meisel, Ivar Roots, Jürgen Brockmöller

Journal:

Clinical Pharmacokinetics

Year:

2004

Language:

english

File:

PDF, 178 KB

english, 2004

31

Effect of Genetic Polymorphisms in Cytochrome P450 (CYP) 2C9 and CYP2C8 on the Pharmacokinetics of Oral Antidiabetic Drugs

Dr Julia Kirchheiner, Ivar Roots, Mark Goldammer, Bernd Rosenkranz, Jürgen Brockmöller

Journal:

Clinical Pharmacokinetics

Year:

2005

Language:

english

File:

PDF, 197 KB

english, 2005

32

Pharmacogenetics of Oral Anticoagulants

Simone Stehle, Julia Kirchheiner, Andreas Lazar, Prof. Dr med. Uwe Fuhr

Journal:

Clinical Pharmacokinetics

Year:

2008

Language:

english

File:

PDF, 260 KB

english, 2008

33

Assessment of Alzheimer's disease risk genes with CSF-biomarker levels

Schjeide, Brit-Maren, Borovecki, Fran, Clarimón, Jordi, Faltraco, Frank, Giedraitis, Vilmantas, Ingelsson, Martin, Hampel, Harald, Hooli, Basavaraj, Kilander, Lena, Kirchheiner, Julia, Klepac, Natasa,

Journal:

Alzheimer's & Dementia

Year:

2013

Language:

english

File:

PDF, 178 KB

english, 2013

34

Pharmacogenetics-Guided Dose Modifications of Antidepressants

Seeringer, Angela, Kirchheiner, Julia

Journal:

Clinics in Laboratory Medicine

Year:

2008

Language:

english

File:

PDF, 181 KB

english, 2008

35

Cytochrome P450 2D6 Genotyping

Dr Julia Kirchheiner,Cristina Rodriguez-Antona

Journal:

Year:

2009

Language:

english

File:

PDF, 150 KB

english, 2009

36

Pharmacogenetics‐Based New Therapeutic Concepts

Roots, Ivar, Gerloff, Thomas, Meisel, Christian, Kirchheiner, Julia, Goldammer, Mark, Kaiser, Rolf, Laschinski, Gabriele, Brockmöller, Jürgen, Cascorbi, Ingolf, Kleeberg, Ullrich, Hildebrandt, Alfred

Journal:

Drug Metabolism Reviews

Year:

2004

Language:

english

File:

PDF, 512 KB

english, 2004

37

Human lymphoblastoid cell line panels: novel tools for assessing shared drug pathways

Morag, Ayelet, Kirchheiner, Julia, Rehavi, Moshe, Gurwitz, David

Journal:

Pharmacogenomics

Year:

2010

Language:

english

File:

PDF, 960 KB

english, 2010

38

Genotype-guided dosing of coumarin derivatives: the European pharmacogenetics of anticoagulant therapy (EU-PACT) trial design

van Schie, Rianne MF, Wadelius, Mia, Kamali, Farhad, Daly, Ann K, Manolopoulos, Vangelis G, de Boer, Anthonius, Barallon, Rita, Verhoef, Talitha I, Kirchheiner, Julia, Haschke-Becher, Elisabeth, Briz,

Journal:

Pharmacogenomics

Year:

2009

Language:

english

File:

PDF, 451 KB

english, 2009

39

Pharmacogenomics || Study Designs in Clinical Pharmacogenetic and Pharmacogenomic Research

Stingl (formerly Kirchheiner), Julia

Year:

2013

Language:

english

File:

PDF, 1.59 MB

english, 2013

40

Genetic variants in FKBP5 affecting response to antidepressant drug treatment

Kirchheiner, Julia, Lorch, Rainer, Lebedeva, Elena, Seeringer, Angela, Roots, Ivar, Sasse, Johanna, Brockmöller, Jürgen

Journal:

Pharmacogenomics

Year:

2008

Language:

english

File:

PDF, 193 KB

english, 2008

41

Pharmacogenetic diagnostics of cytochrome P450 polymorphisms in clinical drug development and in drug treatment

Brockmöller, Jürgen, Kirchheiner, Julia, Meisel, Christian, Roots, Ivar

Journal:

Pharmacogenomics

Year:

2000

Language:

english

File:

PDF, 252 KB

english, 2000

42

Impact of genetic polymorphisms in CYP2C8 and rosiglitazone intake on the urinary excretion of dihydroxyeicosatrienoic acids

Kirchheiner, Julia, Meineke, Ingolf, Fuhr, Uwe, Rodríguez-Antona, Cristina, Lebedeva, Elena, Brockmöller, Jürgen

Journal:

Pharmacogenomics

Year:

2008

Language:

english

File:

PDF, 360 KB

english, 2008

43

The Role of Clusterin, Complement Receptor 1, and Phosphatidylinositol Binding Clathrin Assembly Protein in Alzheimer Disease Risk and Cerebrospinal Fluid Biomarker Levels

Schjeide, Brit-Maren M., Schnack, Cathrin, Lambert, Jean-Charles, Lill, Christina M., Kirchheiner, Julia, Tumani, Hayrettin, Otto, Markus, Tanzi, Rudolph E., Lehrach, Hans, Amouyel, Philippe, von Arni

Journal:

Archives of General Psychiatry

Year:

2011

Language:

english

File:

PDF, 187 KB

english, 2011

44

Translating Pharmacogenomics: Challenges on the Road to the Clinic

Swen, Jesse J., Huizinga, Tom W., Gelderblom, Hans, de Vries, Elisabeth G. E., Assendelft, Willem J. J., Kirchheiner, Julia, Guchelaar, Henk-Jan

Journal:

Year:

2007

Language:

english

File:

PDF, 194 KB

english, 2007

45

Serotonin Syndrome With Tramadol and Citalopram

MAHLBERG, RICHARD, KUNZ, DIETER, SASSE, JOHANNA, KIRCHHEINER, JULIA

Journal:

American Journal of Psychiatry

Year:

2004

Language:

english

File:

PDF, 53 KB

english, 2004

46

Effects of CYP2C9 polymorphisms on the pharmacokinetics of R- and S-phenprocoumon in healthy volunteers

Kirchheiner, Julia, Ufer, Mike, Walter, Ev-Charlotte, Kammerer, Bernd, Kahlich, Rainer, Meisel, Christian, Schwab, Matthias, Gleiter, Christoph H, Rane, Anders, Roots, Ivar, Brockm??ller, J??rgen

Journal:

Pharmacogenetics

Year:

2004

Language:

english

File:

PDF, 141 KB

english, 2004

47

10.1097/00008571-200203000-00004

Kirchheiner, Julia, Bauer, Steffen, Meineke, Ingolf, Rohde, Wolfgang, Prang, Verena, Meisel, Christian, Roots, Ivor, Brockmoller, Jurgen

Journal:

Pharmacogenetics

Year:

2002

Language:

english

File:

PDF, 644 KB

english, 2002

48

Assessment Of Amplichip CYP450 Based CYP2D6-Genotyping And Phenotype Prediction Compared To PCR-RFLP-genotyping And Phenotyping By Metoprolol Pharmacokinetics

Heller, Tanja, Kirchheiner, Julia, Armstrong, Victor W, Luthe, Hilmar, Brockm??ller, J??rgen, Oellerich, Michael

Journal:

Therapeutic Drug Monitoring

Year:

2005

Language:

english

File:

PDF, 691 KB

english, 2005

49

Trimipramine pharmacokinetics after intravenous and oral administration in carriers of CYP2D6 genotypes predicting poor, extensive and ultrahigh activity

Kirchheiner, Julia, Sasse, Johanna, Meineke, Ingolf, Roots, Ivar, Brockm??ller, J??rgen

Journal:

Pharmacogenetics

Year:

2003

Language:

english

File:

PDF, 145 KB

english, 2003

50

Influence of CYP2C9 genetic polymorphisms on pharmacokinetics of celecoxib and its metabolites

Kirchheiner, Julia, St??rmer, Elke, Meisel, Christian, Steinbach, Nadine, Roots, Ivar, Brockm??ller, J??rgen

Journal:

Pharmacogenetics

Year:

2003

Language:

english

File:

PDF, 140 KB

english, 2003